Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea.
نویسندگان
چکیده
منابع مشابه
Glycopyrrolate in comparison to hyoscine hydrobromide and placebo in the treatment of hypersalivation induced by clozapine (GOTHIC1): study protocol for a randomised controlled feasibility study
BACKGROUND Clozapine is the only medication licensed for the treatment of resistant schizophrenia in the UK. Although efficacious, a common and unpopular side effect of clozapine treatment is clozapine-induced hypersalivation (CIH), which can contribute to non-adherence. The standard treatment for CIH in the UK is hyoscine hydrobromide but this may aggravate cognitive deficits in patients with ...
متن کاملAspiration Pneumonia Due to Clozapine-Induced Sialorrhea.
Introduction Clozapine is a second-generation antipsychotic, which use is limited to treatment-resistant cases of schizophrenia. Sialorrhea, a well-known side effect of clozapine, occurs in 31–54% of patients receiving clozapine therapy (1). Patients may complain of both daytime and nighttime drooling (the “wet pillow” sign). Here, we report the case of a young man who developed aspiration pneu...
متن کاملComparative study of the effects of oral and i.m. atropine and hyoscine in volunteers.
The effects of equivalent doses of atropine and hyoscine following oral and i.m. administration were assessed on salivary secretion, heart rate, arterial pressure, body temperature, pupillary size, near-point of vision and sweat-gland activity. The ratio of oral to i.m. doses of atropine on heart rate and salivary secretion appears to be 2:1 and that of hyoscine on salivary secretion about 5-6:...
متن کاملIdentification and determination of different alkaloids from Atropa belladonna L. by Gas chromatography method
Background & Aim: A. belladonna (family: Solanaceae) is one of important pharmaceutical plants which contain tropane alkaloids. Tropane alkaloids are distinct group of secondary metabolites of the Solanaceae family. The most important alkaloids of A. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. There...
متن کاملTrihexyphenidyl (benzhexol) in clozapine-induced nocturnal enuresis and sialorrhea.
Sir, Clozapine is an atypical antipsychotic medication. It is the agent of choice to treat patients with schizophrenia who are treatment-resistant and who are prone to extrapyramidal symptoms. However, besides occasional serious and life-threatening side effects like agranulocytosis, myocarditis, and seizures, clozapine is often discontinued because of many common and troublesome side effects l...
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ورودعنوان ژورنال:
- African journal of psychiatry
دوره 16 4 شماره
صفحات -
تاریخ انتشار 2013